Living Radical Polymerization as a Tool for the Synthesis of Polymer‐Protein/Peptide Bioconjugates
Identifieur interne : 000190 ( France/Analysis ); précédent : 000189; suivant : 000191Living Radical Polymerization as a Tool for the Synthesis of Polymer‐Protein/Peptide Bioconjugates
Auteurs : Julien Nicolas [France] ; Giuseppe Mantovani [Royaume-Uni] ; David M. Haddleton [Royaume-Uni]Source :
- Macromolecular Rapid Communications [ 1022-1336 ] ; 2007-05-16.
English descriptors
- Teeft :
- Acrylamide, Acrylate, Acrylic acid, Active species, Ambient, Ambient temperature, Amidation reaction, Amine, Angew, Aqueous solution, Atom transfer, Atrp, Atrp initiator, Ayres, Azide, Bioconjugate, Bioconjugate chem, Bioconjugates, Bioconjugation, Biohybrid, Biomacromolecules, Biotin, Biotinylated, Block copolymer, Block copolymers, Broad range, Chaikof, Charleux, Chem, Click, Commun, Conjugation, Consecutive atrp, Copolymer, Covalent, Covalent link, Coworkers, Cyclic, Deming, Difunctional atrp initiator, Dmso, Dormant species, Drug delivery, Ester, Functional groups, Functionality, Functionalized, Glycopolymer, Glycopolymers, Gmbh, Gnanou, Good control, Haddleton, Haddleton figure, Hawker, Hest, Hydroxyl groups, Initiator, Kgaa, Kinetic plot, Lcst, Linear evolution, Lutz, Macroinitiator, Macromol, Macromolecular, Macromolecular architectures, Macromolecular moieties, Macromolecule, Mantovani, Matyjaszewski, Methacrylate, Methyl, Methyl acrylate, Miktoarm copolymers, Mild conditions, Model peptide, Moiety, Molar, Molar masses, Molar ratio, Molecular weight, Molecular weights, Monomer, Monomer conversion, Nanoparticles, Nanotube, Nitroxide, Peptide, Peptide sequence, Peptide synthesis, Pnipam, Polydispersity, Polydispersity indices, Polym, Polymer, Polymer brushes, Polymer chain, Polymer chains, Polymerization, Polymerization time, Polymerized, Polypeptide, Preformed, Preformed polymer, Promising results, Propagating radicals, Protein transduction domain, Radical polymerization, Rapid commun, Reactive, Remsen, Reversible termination, Rizzardo, Sequential, Sequential atrp, Sharpless, Streptavidin, Synthetic polymers, Triblock, Triblock copolymer, Triblock copolymers, Uorescence, Uorescent, Verlag, Verlag gmbh, Wang, Weinheim, Wide range, Wooley, Zhang.
Abstract
Combinations of synthetic and natural macromolecules offer a route to new functional materials. While biological and polymer chemistry may not be natural bedfellows, many researchers are focusing their attention on the benefits of combining these fields. Recent advances in living radical polymerization have provided methods to build tailor‐made macromolecular moieties using relatively simple processes. This has led to a plethora of block copolymers, end‐functional polymers and polymers with a whole range of biological recognition abilities. This review covers work carried out until late 2006 combining living radical polymerization with proteins and peptides in the rapidly‐expanding field of bioconjugation.
Url:
DOI: 10.1002/marc.200700112
Affiliations:
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